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Teoh A.N., Kaur S., Shafie S.R., Mohd Shukri N.H., Ahmad Bustami N., Takahashi M., Shibata S.

Chrononutrition is associated with melatonin and cortisol rhythm during pregnancy: Findings from MY-CARE cohort

Frontiers in Nutrition.  2023 Jan, 9:1078086.  doi: 10.3389/fnut.2022.1078086. eCollection 2022. Free PMC article


Xiao K, Furutani A, Sasaki H, Takahashi M, Shibata S.

Effect of a High Protein Diet at Breakfast on Postprandial Glucose Level at Dinner Time in Healthy Adults.

Nutrients. 2022 Dec, 15(1):85. doi: 10.3390/nu15010085.  Free PMC article

Kuwahara M, Tahara Y, Suiko T, Nagamori Y, Shibata S.

Effects of Differences of Breakfast Styles, Such as Japanese and Western Breakfasts, on Eating Habits.

Nutrients​. 2022 Dec, 14(23) 5143.  doi: 10.3390/nu14235143. Free PMC article

Haraguchi A, Yamazaki T, Ryan C, Ito K, Sato S, Tamura K, Sekiguchi M, Cao S, Shibata S.

Caffeine suppresses high-fat diet-induced body weight gain in mice depending on feeding timing.

Journal of Functional Foods. 2022 Dec, 99. doi:10.1016/j.jff.2022.105307. Free PMC article

Kuwahara M, Kim H.-K, Furutani A, Mineshita Y, Nakaoka T, Shibata S.

Effect of lunch with different calorie and nutrient balances on dinner-induced postprandial glucose variability

Nutrition and Metabolism. 2022 Sep, 19(1):65.  doi: 10.1186/s12986-022-00704-1. Free PMC article

Imamura M, Tahara Y, Suiko T, Nagamori Y, Shibata S.

Association between blood pressure and c ircadian timing of physical activity of Japanese workers

Frontiers in Physiology. 2022 Sep, 13, doi: 10.3389/fphys.2022.992945.  Free PMC article


Farnaz Roshanmehr , Yu Tahara, Saneyuki Makino, Ayako Tada, Nanako Abe, Mikiko Michie, Shigenobu Shibata

Association of Japanese Breakfast Intake with Macro- and Micronutrients and Morning Chronotype

Nutrients​. 2022 Aug, 14(17): 3496. doi: 10.3390/nu14173496.  Free PMC article

Hyeon-Ki Kim , Shota Furuhashi , Masaki Takahashi, Hanako Chijiki , Takuya Nanba, Takayuki Inami, Zsolt Radak, Shizuo Sakamoto, Shigenobu Shibata 

Late-afternoon endurance exercise is more effective than morning endurance exercise at improving 24-h glucose and blood lipid levels

Front Endocrinol (Lausanne). 2022 Jul ,13: 957239. doi: 10.3389/fendo. eCollection 2022. Free PMC article

Farnaz Roshanmehr , Katsuki Hayashi, Yu Tahara, Takahiko Suiko, Yuki Nagamori, Takao Iwai, Shigenobu Shibata

Association between Breakfast Meal Categories and Timing of Physical Activity of Japanese Workers

Foods. 2022 Aug,11(17): 2609.  doi:10.3390/foods11172609. Free PMC article

Yui Mineshita , Hiroyuki Sasaki, Hyeon-Ki Kim , Shigenobu Shibata.

Relationship between Fasting and Postprandial Glucose Levels and the Gut Microbiota

Metabolites. 2022Jul, 12(7): 669. doi: 10.3390/metabo12070669. Free PMC article


Shinto T., Makino S., Tahara Y., Nitta L., Kuwahara M., Tada A., Abe N., Michie M., Shibata S.

Relationship Between Protein Intake in Each Traditional Meal and Physical Activity: Cross-sectional Study

JMIR Public Health and Surveillance. 2022Aug, 8(7):e35898. doi: 10.2196/35898. Free PMC article

Haraguchi, A., Du, Y., Shiraishi, R., Takahashi, Y., Nakamura, T.J., Shibata, S.

Oak extracts modulate circadian rhythms of clock gene expression in vitro and wheel-running activity in mice.

Sleep and Biological Rhythms. 2022Apr, 20(2): Free PMC article


Haraguchi A, Saito K, Tahara Y, Shibata S.

Polygalae Radix shortens the circadian period through activation of the CaMKII pathway.

Pharm Biol. 2022 Dec, 60(1) :689-698. doi: 10.1080/13880209.2022.2048863. Free PMC article.


Sasaki H, Miyakawa H, Watanabe A, Tamura K, Shiga K, Lyu Y, Ichikawa N, Fu Y, Hayashi K, Imamura M, Shibata S.

Evening rather than morning increased physical activity alters the microbiota in mice and is associated with increased body temperature and sympathetic nervous system activation.

Biochim Biophys Acta Mol Basis Dis. 2022 Jun , 1868(6):166373. doi: 10.1016/j.bbadis.2022.166373. Epub 2022 Mar 11.



Imamura M, Sasaki H, Shinto T, Tahara Y, Makino S, Kuwahara M, Tada A, Abe N, Michie M, Shibata S.

Association Between Na, K, and Lipid Intake in Each Meal and Blood Pressure.

Front Nutr. 2022 Mar 4;9:853118. doi: 10.3389/fnut.2022.853118. eCollection 2022.

Ichikawa N, Ng LS, Makino S, Goh LL, Lim YJ, Ferdinandus, Sasaki H, Shibata S, Lee CK. 

Solid-State Fermented Okara with Aspergillus spp. Improves Lipid Metabolism and High-Fat Diet Induced Obesity

Metabolites. 2022 Feb 23;12(3):198. doi: 10.3390/metabo12030198. Free PMC article

Oneda S , Cao S, Haraguchi A , Sasaki H , Shibata S.

Wheel-Running Facilitates Phase Advances in Locomotor and Peripheral Circadian Rhythm in Social Jet Lag Model Mice

Front Physiol​, 2022 Feb 16;13:821199. doi: 10.3389/fphys.2022.821199. eCollection 2022. Free PMC article


Asama Y, Furutani A, Fujioka M , Ozawa H, Takei S , Shibata S, Ogawa K

Analysis of conductive olfactory dysfunction using computational fluid dynamics

PLoS One​. 2022 Jan 12;17(1):e0262579.doi: 10.1371/journal.pone.0262579. eCollection 2022. Free PMC article


Ichikawa N, Sasaki H, Lyu Y, Furuhashi S, Watabe A, Imamura M, Hayashi K, Shibata S.

Cold Exposure during the Active Phase Affects the Short-Chain Fatty Acid Production of Mice in a Time-Specific Manner

Metabolites​. 2021 Dec 27;12(1):20.doi: 10.3390/metabo12010020. Free PMC article

Kim HK, Chijiki HFukazawa MOkubo J, Ozaki M ,Nanba THigashi SShioyama MTakahashi MNakaoka TShibata S.

Supplementation of Protein at Breakfast Rather Than at Dinner and Lunch Is Effective on Skeletal Muscle Mass in Older Adults

Front Nutr​. 2021 Dec 21;8:797004. doi: 10.3389/fnut.2021.797004. eCollection 2021. Free PMC article

Mineshita Y, Kim HK, Shinto T, Kuwahara M, Shibata S.

Attending a Sports Club Can Help Prevent Visual Impairment Caused by Cram School in Elementary School Children in Japan.

Int J Environ Res Public Health. 2021 Nov 26;18(23):12440. doi: 10.3390/ijerph182312440.PMID: 34886166 Free PMC article.

Tahara Y, Shinto T, Inoue K, Roshanmehr F, Ito A, Michie M, Shibata S.

Changes in sleep phase and body weight of mobile health App users during COVID-19 mild lockdown in Japan.

Int J Obes (Lond). 2021 Oct;45(10):2277-2280. doi: 10.1038/s41366-021-00890-7. Epub 2021 Jul 3.PMID: 34218262 Free PMC article.

Tahara Y, Makino S, Suiko T, Nagamori Y, Iwai T, Aono M, Shibata S.

Association between Irregular Meal Timing and the Mental Health of Japanese Workers.

Nutrients. 2021 Aug 13;13(8):2775. doi: 10.3390/nu13082775.PMID: 34444937 Free PMC article.

Aoyama S, Kim HK, Hirooka R, Tanaka M, Shimoda T, Chijiki H, Kojima S, Sasaki K, Takahashi K, Makino S, Takizawa M, Takahashi M, Tahara Y, Shimba S, Shinohara K, Shibata S.

Distribution of dietary protein intake in daily meals influences skeletal muscle hypertrophy via the muscle clock.

Cell Rep. 2021 Jul 6;36(1):109336. doi: 10.1016/j.celrep.2021.109336.PMID: 34233179  Free article.

Teoh AN, Kaur S, Mohd Shukri NH, Shafie SR, Ahmad Bustami N, Takahashi M, Lim PJ, Shibata S.

Psychological state during pregnancy is associated with sleep quality: preliminary findings from MY-CARE cohort study.

Chronobiol Int. 2021 Mar 28:1-12. doi: 10.1080/07420528.2021.1902338. Online ahead of print.PMID: 33779445

Komada Y, Sato M, Ikeda Y, Kami A, Masuda C, Shibata S.

The Relationship between the Lunar Phase, Menstrual Cycle Onset and Subjective Sleep Quality among Women of Reproductive Age.

Int J Environ Res Public Health. 2021 Mar 21;18(6):3245. doi: 10.3390/ijerph18063245.PMID: 33801068

Mineshita Y, Kim HK, Chijiki H, Nanba T, Shinto T, Furuhashi S, Oneda S, Kuwahara M, Suwama A, Shibata S.

Screen time duration and timing: effects on obesity, physical activity, dry eyes, and learning ability in elementary school children.

BMC Public Health. 2021 Feb 28;21(1):422. doi: 10.1186/s12889-021-10484-7.PMID: 33639912

Omori K, Miyakawa H, Watanabe A, Nakayama Y, Lyu Y, Ichikawa N, Sasaki  H, Shibata S.

The Combined Effects of Magnesium Oxide and Inulin on Intestinal Microbiota and Cecal Short-Chain Fatty Acids.

Nutrients.2021 Jan 5;13(1);152. doi: 10.3390/nu13010152.   PMID:33466274 Free PMC article.



Haraguchi A, Nishimura Y, Fukuzawa M, Kikuchi Y, Tahara Y, Shibata S.

Use of a social jetlag-mimicking mouse model to determine the effects of a two-day delayed light-and/or feeding-shift on central and peripheral clock rhythms plus cognitive functioning.

Chronobiol Int. 2020 Dec 20:1-17. doi: 10.1080/07420528.2020.1858850. Online ahead of print. PMID:33345638


T Takahashi, T Haitani, F Tanaka, T Yamagishi, Y Kawakami, S Shibata, H Kumano.

Effects of the time-of-day (morning vs. afternoon) of implementing a combined physical and cognitive exercise program on cognitive functions and mood of older adults: A randomized controlled study

Adv Gerontol 2020;33(3):595-599.  PMID: 33280348

Kim HK, Chijiki H, Nanba T, Ozaki M, Sasaki H, Masaki T.

Ingestion of Helianthus tuberosus at Breakfast Rather Than at Dinner Is More Effective for Suppressing Glucose Levels and Improving the Intestinal Microbiota in Older Adults.

Nutrients. 2020 Oct 3;12(10):E3035. doi: 10.3390/nu12103035.PMID: 33022987

Kim HK, Nanba T, Ozaki M, Chijiki H, Takahashi M, Fukazawa M, Okubo J, Shibata S.

Effect of the Intake of a Snack Containing Dietary Fiber on Postprandial Glucose Levels.

Foods. 2020 Oct 20;9(10):1500. doi: 10.3390/foods9101500.PMID: 33092177 

Akter S, Uddin KR, Sasaki H, Shibata S.

Gamma Oryzanol Alleviates High-Fat Diet-Induced Anxiety-Like Behaviors Through Downregulation of Dopamine and Inflammation in the Amygdala of Mice.

Front Pharmacol. 2020 Mar 17;11:330. doi: 10.3389/fphar.2020.00330. eCollection 2020.PMID: 32256371 Free PMC article.

Kuwahara M, Kim HK, Ozaki M, Nanba T, Chijiki H, Fukazawa M, Okubo J, Mineshita Y, Takahashi M, Shibata S

Consumption of Biscuits with a Beverage of Mulberry or Barley Leaves in the Afternoon Prevents Dinner-Induced High, but Not Low, Increases in Blood Glucose among Young Adults.

Nutrients. 2020 May 28;12(6):1580. doi: 10.3390/nu12061580.PMID: 32481557 Free PMC article.


Sasaki H, Lyu Y, Nakayama Y, Nakamura F, Watanabe A, Miyakawa H, Nakao Y, Shibata S

Combinatorial Effects of Soluble, Insoluble, and Organic Extracts from Jerusalem Artichokes on Gut Microbiota in Mice.

Microorganisms. 2020 Jun 24;8(6):E954. doi: 10.3390/microorganisms8060954.PMID: 32599833 Free article.

S, Uddin KR, Sasaki H, Lyu Y, Shibata S

Gamma oryzanol impairs alcohol-induced anxiety-like behavior in mice via upregulation of central monoamines associated with Bdnf and Il-1β signaling.

Sci Rep. 2020 Jun 30;10(1):10677. doi: 10.1038/s41598-020-67689-w.PMID: 32606350 Free PMC article.

Aoyama S, ShibataS.

Time-of-Day-Dependent Physiological Responses to Meal and Exercise.

Front Nutr. 2020 Feb 28;7:18. doi: 10.3389/fnut.2020.00018. eCollection 2020. Review.

PMID:32181258  Free PMC Article

Orihara K, Haraguchi A, Shibata S.

Crosstalk Among Circadian Rhythm, Obesity and Allergy.

Int J Mol Sci. 2020 Mar 10;21(5). pii: E1884. doi: 10.3390/ijms21051884. Review.

PMID: 32164209 Free PMC Article

Takahashi M, Ozaki M, Tsubosaka M, Kim HK, Sasaki H, Matsui Y, Hibi M, Osaki N, Miyashita M, Shibata S.

Effects of Timing of Acute and Consecutive Catechin Ingestion on Postprandial Glucose Metabolism in Mice and Humans.

Nutrients. 2020 Feb 21;12(2). pii: E565. doi: 10.3390/nu12020565.

PMID: 32098219 Free PMC Article

Kaur S, Teoh AN, Shukri NHM, Shafie SR, Bustami NA, Takahashi M, Lim PJ, Shibata S.

Circadian rhythm and its association with birth and infant outcomes: research protocol of a prospective cohort study.

BMC Pregnancy Childbirth. 2020 Feb 11;20(1):96. doi: 10.1186/s12884-020-2797-2.

PMID: 32046676 Free PMC Article

Watanabe A, Sasaki H, Miyakawa H, Nakayama Y, Lyu Y, Shibata S.

Effect of Dose and Timing of Burdock (Arctium lappa) Root Intake on Intestinal Microbiota of Mice.

Microorganisms. 2020 Feb 6;8(2). pii: E220. doi: 10.3390/microorganisms8020220.

PMID:  32041173 Free Article

Motohashi H, Tahara Y, Whittaker DS, Wang HB, Yamaji T, Wakui H, Haraguchi A, Yamazaki M, Miyakawa H, Hama K, Sasaki H, Sakai T, Hirooka R, Takahashi K, Takizawa M, Makino S, Aoyama S, Colwell CS, Shibata S.

The circadian clock is disrupted in mice with adenine-induced tubulointerstitial nephropathy.

PMID: 32046676 Free PMC Article


Tamura K, Sasaki H, Shiga K, Miyakawa H. Shibata S.

The Timing Effects of Soy Protein Intake on Mice Gut Microbiota.

Nutrients.2019 Dec 27;12(1). pill: E87. doi: 10.3390/nu12010087.

PMID: 31892229    Free Article

Tateishi N, Morita S, Yamazaki I, Okumura H, Kominami M, Akazawa S, Funaki A, Tomimori N, Rogi T, Shibata H, Shibata S.

Administration timing and duration-dependent effects of sesamin isomers on lipid metabolism in rats.

Chronobiol Int 2019 Dec 13:1-17. doi: 10.1080/07420528.2019.1700998 [Epub ahead of print]

PMID: 31833423

Chan LY, Takahashi M, Lim PJ, Aoyama S, Makino S, Ferdinandus F, Ng SYC, Arai S, Fujita H, Tan HC, Shibata S, Lee CK.

Eurotium Cristatum Fermented Okara as a Potential Food Ingredient to Combat Diabetes.

Sci Rep. 2019 Nov 26;9(1):17536. doi: 10.1038/s41598-019-54021-4. PMID:31772240

Sasaki H, Miyakawa H, Watanabe A, Nakayama Y, Lyu Y, Hama K, Shibata S.

Mice Microbiota Composition Changes by Inulin Feeding with a Long Fasting Period under a Two-Meals-Per-Day Schedule.

Nutrients. 2019 Nov 16;11(11). pii: E2802. doi: 10.3390/nu11112802. PMID:31744168

Aoyama S, Hirooka R, Shimoda T, Shibata S.

Effect of different sources of dietary protein on muscle hypertrophy in functionally overloaded mice.

Biochem Biophys Rep. 2019 Sep 10;20:100686. doi: 10.1016/j.bbrep.2019.100686. eCollection 2019 Dec.


Takahashi M, Ozaki M, Miyashita M, Fukazawa M, Nakaoka T, Wakisaka T, Matsui Y, Hibi M, Osaki N, Shibata S.

Effects of timing of acute catechin-rich green tea ingestion on postprandial glucose metabolism in healthy men.

J Nutr Biochem. 2019 Nov;73:108221. doi: 10.1016/j.jnutbio.2019.108221. Epub 2019 Aug 15. PMID:31522082

Takahashi M, Lim PJ, Tsubosaka M, Kim HK, Miyashita M, Suzuki K, Tan EL, Shibata S.

Effects of increased daily physical activity on mental health and depression biomarkers in postmenopausal women.

J Phys Ther Sci. 2019 Apr;31(4):408-413. doi: 10.1589/jpts.31.408. Epub 2019 Apr 1. PMID:31037019

Yasuda S, Iwami S, Tamura K, Ikeda Y, Kamagata M, Sasaki H, Haraguchi A, Miyamatsu M, Hanashi S, Takato Y, Shibata S.

Phase resetting of circadian peripheral clocks using human and rodent diets in mouse models of type 2 diabetes and chronic kidney disease.

Chronobiol Int. 2019 Jun;36(6):851-869. doi: 10.1080/07420528.2019.1594245. Epub 2019 Apr 16. PMID:30990101

Haraguchi A, Komada Y, Inoue Y, Shibata S.

Correlation among clock gene expression rhythms, sleep quality, and meal conditions in delayed sleep-wake phase disorder and night eating syndrome.

Chronobiol Int. 2019 Jun;36(6):770-783. doi: 10.1080/07420528.2019.1585366. Epub 2019 Mar 28. PMID:30917702

Hattammaru M, Tahara Y, Kikuchi T, Okajima K, Konishi K, Nakajima S, Sato K, Otsuka K, Sakura H, Shibata S, Nakaoka T.

The effect of night shift work on the expression of clock genes in beard hair follicle cells.

Sleep Med. 2019 Jan 17. pii: S1389-9457(18)30593-8. doi: 10.1016/j.sleep.2019.01.005. [Epub ahead of print]

PMID: 30803832

Akter S, Sasaki H, Uddin KR, Ikeda Y, Miyakawa H, Shibata S.

Anxiolytic effects of γ-oryzanol in chronically- stressed mice are related to monoamine levels in the brain.

Life Sci. 2019 Jan 1;216:119-128. doi: 10.1016/j.lfs.2018.11.042. Epub 2018 Nov 20. PMID:30468832

Taira A, Arita E, Matsumoto E, Oohira A, Iwase K, Hiwasa T, Yokote K, Shibata S, Takiguchi M.

Systemic oscillator-driven and nutrient-responsive hormonal regulation of daily expression rhythms for gluconeogenic enzyme genes in the mouse liver.

Chronobiol Int. 2019 Feb 3:1-25. doi: 10.1080/07420528.2019.1570246. [Epub ahead of print]

PMID: 30714432

Yasuda S, Iwami S, Tamura K, Ikeda Y, Kamagata M, Sasaki H, Haraguchi A, Miyamatsu M, Hanashi S, Takato Y, Shibata S.

Phase resetting of circadian peripheral clocks using human and rodent diets in mouse models of type 2 diabetes and chronic kidney disease.

Chronobiol Int. 2019 Jun;36(6):851-869. doi: 10.1080/07420528.2019.1594245. Epub 2019 Apr 16. PMID:30990101

Takahashi M, Ozaki M, Miyashita M, Fukazawa M, Nakaoka T, Wakisaka T, Matsui Y, Hibi M, Osaki N, Shibata S.

Effects of timing of acute catechin-rich green tea ingestion on postprandial glucose metabolism in healthy men.

J Nutr Biochem. 2019 Nov;73:108221. doi: 10.1016/j.jnutbio.2019.108221. Epub 2019 Aug 15. PMID:31522082

Takahashi M, Lim PJ, Tsubosaka M, Kim HK, Miyashita M, Suzuki K, Tan EL, Shibata S.

Effects of increased daily physical activity on mental health and depression biomarkers in postmenopausal women.

J Phys Ther Sci. 2019 Apr;31(4):408-413. doi: 10.1589/jpts.31.408. Epub 2019 Apr 1. PMID:31037019

Yamamoto T,Iwami S, Aoyama S,Uchida HM, Mori S,Hirooka R,Takahashi K,Morita M, Shibata S.

Effect of piceatannol on circadian Per2 expression in vitoro and in vivo.  

Journal of Functional Foods. 2019 Feb ;56 (2019) 49-56.

Furutani A, Asama Y, Sasaki  H, Shibata S

Refined Auditory Brainstem Response Measurement Identified Potential Models of Congenital Deafness in Laboratory Mouse Strains 

JMA Journal.    2019 Feb ;10.31662/jmaj.2018-0067


Akter S, Sasaki H, Uddin KR, Ikeda Y, Miyakawa H, Shibata S. 

Anxiolytic effects of γ-oryzanol in chronically- stressed mice are related to monoamine levels in the brain.

Life Sci. 2018 Nov 20. pii: S0024-3205(18)30763-X. doi: 10.1016/j.lfs.2018.11.042. [Epub ahead of print]

PMID: 30468832

Shibata S, Furutani A.

[Chrono-nutrition and n-3 polyunsaturated fatty acid]

Nihon Yakurigaku Zasshi. 2018;151(1):34-40. doi: 10.1254/fpj.151.34. Japanese.

Takahashi M, Ozaki M, Kang MI, Sasaki H, Fukazawa M, Iwakami T, Lim PJ, Kim HK, Aoyama S, Shibata S.

Effects of Meal Timing on Postprandial Glucose Metabolism and Blood Metabolites in Healthy Adults.

Nutrients. 2018 Nov 14;10(11). pii: E1763. doi: 10.3390/nu10111763. PMID: 30441841

Yoshida T, Yamada Y, Tanaka F, Yamagishi T, Shibata S, Kawakami Y.

Intracellular-to-total water ratio explains the variability of muscle strength dependence on the size of the lower leg in the elderly.

Exp Gerontol. 2018 Nov;113:120-127. doi: 10.1016/j.exger.2018.09.022. Epub 2018 Sep 27. PMID: 30267871

Komada Y, Ikeda Y, Sato M, Kami A, Masuda C, Shibata S.

Social jetlag and menstrual symptoms among female university students.

Chronobiol Int. 2018 Nov 5:1-7. doi: 10.1080/07420528.2018.1533561. [Epub ahead of print] PMID:30395733

Yokota SI, Nakamura K, Ando M, Haraguchi A, Omori K, Shibata S.

A low-protein diet eliminates the circadian rhythm of serum insulin and hepatic lipid metabolism in mice.

J Nutr Biochem. 2018 Oct 11;63:177-185. doi: 10.1016/j.jnutbio.2018.10.004. [Epub ahead of print]

PMID: 30412906

Aoyama S, Kojima S, Sasaki K, Ishikawa R, Tanaka M, Shimoda T, Hattori Y, Aoki N, Takahashi K, Hirooka R, Takizawa M, Haraguchi A, Shibata S. 

Day-Night Oscillation of Atrogin1 and Timing-Dependent Preventive Effect of Weight-Bearing on Muscle Atrophy.

EBioMedicine. 2018 Oct 31. pii: S2352-3964(18)30480-8. doi: 10.1016/j.ebiom.2018.10.057. [Epub ahead of print] PMID: 30391495

Whittaker DS, Loh DH, Wang HB, Tahara Y, Kuljis D, Cutler T, Ghiani CA, Shibata S, Block GD, Colwell CS.

Circadian-based Treatment Strategy Effective in the BACHD Mouse Model of Huntington's Disease.

J Biol Rhythms. 2018 Oct;33(5):535-554. doi: 10.1177/0748730418790401. Epub 2018 Aug 7.

PMID: 30084274

Fukuda T, Haraguchi A, Takahashi M, Nakaoka T, Fukazawa M, Okubo J, Ozaki M, Kanatome A, Ohya R, Miura Y, Obara K, Shibata S.

A randomized, double-blind and placebo-controlled crossover trial on the effect of l-ornithine ingestion on the human circadian clock.

Chronobiol Int. 2018 Sep;35(10):1445-1455. doi: 10.1080/07420528.2018.1490315. Epub 2018 Jul 3.

PMID: 29969301

Akter S, Sasaki H, Ikeda Y, Miyakawa H, Shibata S.

γ-oryzanol ameliorates the acute stress induced by behavioral anxiety testing in mice.

J Pharmacol Sci. 2018 Jun 7. pii: S1347-8613(18)30104-X. doi: 10.1016/j.jphs.2018.06.003. [Epub ahead of print] PMID: 30322802


Takahashi M, Tahara Y, Tsubosaka M, Fukazawa M, Ozaki M, Iwakami T, Nakaoka T, Shibata S.

Chronotype and social jetlag influence human circadian clock gene expression

Sci Rep. 2018 Jul 5;8(1):10152. doi: 10.1038/s41598-018-28616-2. PMID: 2997693

Tsurudome Y, Koyanagi S, Kanemitsu T, Katamune C, Oda M, Kanado Y, Kato M, Morita A, Tahara Y, Matsunaga N, Shibata S, Ohdo S. 

Circadian clock component PERIOD2 regulates diurnal expression of Na+/H+ exchanger regulatory factor-1 and its scaffolding function.

Sci Rep. 2018 Jun 13;8(1):9072. doi: 10.1038/s41598-018-27280-w

Ikeda Y, Kamagata M, Hirao M, Yasuda S, Iwami S, Sasaki H, Tsubosaka M, Hattori Y, Todoh A, Tamura K, Shiga K, Ohtsu T, Shibata S. 

Glucagon and/or IGF-1 Production Regulates Resetting of the Liver Circadian Clock in Response to a Protein or Amino Acid-only Diet.

EBioMedicine. 2018 Feb;28:210-224. doi: 10.1016/j.ebiom.2018.01.012. Epub 2018 Jan 31.


Tahara Y, Yamazaki M, Sukigara H, Motohashi H, Sasaki H, Miyakawa H, Haraguchi A, Ikeda Y, Fukuda S, Shibata S. 

Gut Microbiota-Derived Short Chain Fatty Acids Induce Circadian Clock Entrainment in Mouse Peripheral Tissue.

Sci Rep. 2018 Jan 23;8(1):1395. doi: 10.1038/s41598-018-19836-7.


Haraguchi A, Fukuzawa M, Iwami S, Nishimura Y, Motohashi H, Tahara Y, Shibata S. 

Night eating model shows time-specific depression-like behavior in the forced swimming test.

Sci Rep. 2018 Jan 18;8(1):1081. doi: 10.1038/s41598-018-19433-8.



Tahara Y, Shibata S

Entrainment of the mouse circadian clock: Effects of stress, exercise, and nutrition.

Free Radic Biol Med. 2017 Dec 23.  pii: S0891-5849(17)31278-9. doi: 10.1016

Wada M, Orihara K, Kamagata M, Hama K, Sasaki H, Haraguchi A, Miyakawa H, Nakao A, Shibata S.

Circadian clock-dependent increase in salivary IgA secretion modulated by sympathetic receptor activation in mice.

Sci Rep. 2017 Aug 18;7(1):8802.

Yamasaki T, Deki-Arima N, Kaneko A, Miyamura N, Iwatsuki M, Matsuoka M, Fujimori-Tonou N, Okamoto-Uchida Y, Hirayama J, Marth JD, Yamanashi Y, Kawasaki H, Yamanaka K, Penninger JM, Shibata S, Nishina H.

Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7.

Sci Rep. 2017 Aug 4;7(1):7348.  


Motohashi H, Sukigara H, Tahara Y, Saito K, Yamazaki M, Shiraishi T, Kikuchi Y, Haraguchi A, Shibata S.

Polyporus and Bupleuri radix effectively alter peripheral circadian clock phase acutely in male mice. 

Nutr Res. 2017 Jul;43:16-24.

Kamagata M, Ikeda Y, Sasaki H, Hattori Y, Yasuda S, Iwami S, Tsubosaka M, Ishikawa R, Todoh A, Tamura K, Tahara Y, Shibata S.

Potent synchronization of peripheral circadian clocks by glucocorticoid injections in PER2::LUC-Clock/Clock mice.

Chronobiol Int. 2017 Jul 13:1-16.


Kawauchi T, Ishimaru K, Nakamura Y, Nakano N, Hara M, Ogawa H, Okumura K, Shibata S, Nakao A.

Clock-dependent temporal regulation of IL-33/ST2-mediated mast cell response.

Allergol Int. 2017 Jul;66(3):472-478.

Tahara Y, Takatsu Y, Shiraishi T, Kikuchi Y, Yamazaki M, Motohashi H, Muto A, Sasaki H, Haraguchi A, Kuriki D, Nakamura TJ,Shibata S.

Age-related circadian disorganization caused by sympathetic dysfunction in peripheral clock regulation.  

NPJ Aging Mech Dis. 2017 Jan 5;3:16030.  


Aoyama S, Shibata S.

The Role of Circadian Rhythms in Muscular and Osseous Physiology and Their Regulation by Nutrition and Exercise.

Front Neurosci. 2017 Feb 14;11:63.

Shinozaki A, Misawa K, Ikeda Y, Haraguchi A, Kamagata M, Tahara Y, Shibata S.

Potent Effects of Flavonoid Nobiletin on Amplitude, Period, and Phase of the Circadian Clock Rhythm in PER2::LUCIFERASE Mouse Embryonic Fibroblasts.

PLoS One. 2017 Feb 2;12(2):e0170904.

Nakamura Y, Ishimaru K, Shibata S, Nakao A.
Regulation of plasma histamine levels by the mast cell clock and its modulation by stress.

Sci Rep. 2017 Jan 11;7:39934.

Takahashi M, Haraguchi A, Tahara Y, Aoki N, Fukazawa M, Tanisawa K, Ito T, Nakaoka T, Higuchi M,Shibata S.

Positive association between physical activity and PER3 expression in older adults.

Sci Rep. 2017 Jan 3;7:39771.

Tahara Y, Shibata S.

Abnormal tuning of the hepatic circadian metabolic rhythms in lung cancer.

Hepatology. 2017 Mar;65(3):1061-1064.

 Tahara Y, Aoyama S, Shibata S,

The mammalian circadian clock and its entrainment by stress and exercise.

J Physiological Science, 2017, 76:1-10. 


 Tahara Y , Shibata S

Abnormal tuning of the hepatic circadian metabolic rhythms in lung cancer.

Hepatology, 2016, 65:1061-1064.

 Tahara Y, Shibata S

Circadian rhythms of liver physiology and disease: experimental and clinical evidence

 Nature Reviews Gastroenterology and Hepatology, 2016, 13:217-226.

Tahara Y, Yokota A, Shiraishi T, Yamada S, Haraguchi A, Shinozaki A,Shibata S
In vitro and in vivo Phase Changes of the Mouse CircadianClock by Oxidative Stress, Journal of Circadian Rhythms, 
2016, 14:1-7

Sasaki H, Hattori Y, Ikeda Y, Kamagata M, Iwami S, Yasuda S, Tahara Y, Shibata S.
Forced rather than voluntary exercise entrains peripheral clocks via a corticosterone/noradrenaline increase in PER2::LUC mice.
Sci Rep. 2016 Jun 8;6:27607.

Sasaki H, Hattori Y, Ikeda Y, Kamagata M, Iwami S, Yasuda S, Shibata S.
Phase shifts in circadian peripheral clocks caused by exercise are dependent on the feeding schedule in PER2::LUC mice.
Chronobiol Int. 2016 Apr 28:1-14.

Tahara Y, Aoyama S, Shibata S.
The mammalian circadian clock and its entrainment by stress and exercise.
J Physiol Sci. 2016 Apr 15.



Katamune C, Koyanagi S, Shiromizu S, Matsunaga N, Shimba S, Shibata S,Ohdo S.
Different roles of negative and positive components of the circadian clock in oncogene-induced neoplastic transformation.
J Biol Chem. 2016 Mar 9.

Tahara Y, Shibata S.
Circadian rhythms of liver physiology and disease: experimental and clinical evidence.
Nat Rev Gastroenterol Hepatol. 2016 Feb 24.

Nakamura Y, Nakano N, Ishimaru K, Ando N, Katoh R, Suzuki-Inoue K, Koyanagki S, Ogawa H, Okumura K, Shibata S, Nakao A.
Inhibition of IgE-mediated allergic reactions by pharmacologically targeting the circadian clock.
J Allergy Clin Immunol., J Allergy Clin Immunol. 2015 Nov 7.

Moriya S, Tahara Y, Sasaki H, Ishigooka J, Shibata S.
Phase-delay in the light-dark cycle impairs clock gene expression and levels of serotonin, norepinephrine, and their metabolites in the mouse hippocampus and amygdala.
Sleep Med. 2015 Nov;16(11):1352-9.

Hamaguchi Y, Tahara Y, Hitosugi M, Shibata S.
Impairment of Circadian Rhythms in Peripheral Clocks by Constant Light Is Partially Reversed by Scheduled Feeding or Exercise.
J Biol Rhythms.30(6):533-42. 2015 Oct 14

Tanabe K, Kitagawa E, Wada M, Haraguchi A, Orihara K, Tahara Y, Nakao A, Shibata S.
Antigen exposure in the late light period induces severe symptoms of food allergy in an OVA-allergic mouse model.
Sci Rep. 2015 Sep 30;5:14424

Hamaguchi Y, Tahara Y, Kuroda H, Haraguchi A, Shibata S.
Entrainment of mouse peripheral circadian clocks to <24 h feeding/fasting cycles under 24 h light/dark conditions.
Sci Rep. 2015 Sep 23;5:14207

Yoshida D, Aoki N, Tanaka M, Aoyama S, Shibata S.
The circadian clock controls fluctuations of colonic cell proliferation during the light/dark cycle via feeding behavior in mice.
Chronobiol Int,2015 Oct;32(8):1145-55

Ando N, Nakamura Y, Aoki R, Ishimaru K, Ogawa H, Okumura K, Shibata S, Shimada S, Nakao A.
Circadian Gene Clock Regulates Psoriasis-Like Skin Inflammation in Mice.
J Invest Dermatol,2015 Aug 20

Furutani A, Ikeda Y, Itokawa M, Nagahama H, Ohtsu T, Furutani N, Kamagata M, Yang ZH, Hirasawa A, Tahara Y, Shibata S.
Fish Oil Accelerates Diet-Induced Entrainment of the Mouse Peripheral Clock via GPR120.
PLoS ONE,2015 Jul 10,10:e0132472

Yu Tahara, Takuya Shiraishi, Yosuke Kikuchi, Atsushi Haraguchi, Daisuke Kuriki, Hiroyuki Sasaki, Hiroaki Motohashi, Tomoko Sakai & Shigenobu Shibata
Entrainment of the mouse circadian clock by sub-acute physical and psychological stress
Scientific Reports. 2015 June 15, Article number:11417

Sasaki H, Hattori Y, Ikeda Y, Kamagata M, Shibata S
Eating meals before wheel-running exercise attenuate high fat diet-driven obesity in mice under two meals per day schedule.
Chronobiol Int. 2015 Jun;32(5):677-86.

Moriya S, Tahara Y, Sasaki H, Ishigooka J, Shibata S. 
Housing under abnormal light-dark cycles attenuates day/night expression rhythms of the clock genes Per1, Per2, and Bmal1 in the amygdala and hippocampus of mice.
Neuroscience Research. 2015 May 27

Nakao A, Nakamura Y, Shibata S.
The circadian clock functions as a potent regulator of allergic reaction.
Allergy.2015 May;70(5):467-73

Hamada T, Miyakawa K, Kushige H, Shibata S, Kurachi S.
Age-related expression analysis of mouse liver nuclear protein binding to 3'-untranslated region of Period2 gene.
J Physiol Sci. 2015 Apr 7



Yokota S, Nakamura K, Ando M, Kamei H, Hakuno F, Takahashi S, Shibata S.
Acetylcholinesterase (AChE) inhibition aggravates fasting-induced triglyceride accumulation in the mouse liver
FEBS Open Bio. 2014 Oct 22;4:905-14

Ikeda Y, Sasaki H, Ohtsu T, Shiraishi T, Tahara Y, Shibata S.
Feeding and adrenal entrainment stimuli are both necessary for normal circadian oscillation of peripheral clocks in mice housed under different photoperiods.
Chronobiol Int.2015 Mar;32(2):195-210

Narishige S, Kuwahara M, Shinozaki A, Okada S, Ikeda Y, Kamagata M, Tahara Y, Shibata S.
Effects of caffeine on circadian phase, amplitude, and period evaluated in cells in vitro and peripheral organs in vivo in PER2:LUCIFERASE mice.
Br J Pharmacol.2014 Dec;171(24):5858-69

Aoki N, Yoshida D, Ishikawa R, Ando M, Nakamura K, Tahara Y, Shibata S.
A single daily meal at the beginning of the active or inactive period inhibits food deprivation-induced fatty liver in mice.
Nutr Res. 2014 Jul;34(7):613-22

Okamura A, Koyanagi S, Dilxiat A, Kusunose N, Chen JJ, Matsunaga N, Shibata S, Ohdo S.
Bile Acid-regulated Peroxisome Proliferator-activated Receptor-α (PPARα) Activity Underlies Circadian Expression of Intestinal Peptide Absorption Transporter PepT1/Slc15a1.
J Biol Chem. 2014 Sep 5;289(36):25296-305

Sasaki H, Ohtsu T, Ikeda Y, Tsubosaka M, Shibata S.
Combination of meal and exercise timing with a high-fat diet influences energy expenditure and obesity in mice.
Chronobiol Int. 2014 Nov;31(9):959-75

Haraguchi A, Aoki N, Ohtsu T, Ikeda Y, Tahara Y, Shibata S.
Controlling access time to a high-fat diet during the inactive period protects against obesity in mice.
Chronobiol Int. 2014 Oct;31(8):935-44

Moriya S, Tahara Y, Sasaki H, Hamaguchi Y, Kuriki D, Ishikawa R, Ishigooka J, Shibata S.
Effect of quetiapine on Per1, Per2, and Bmal1 clock gene expression in the mouse amygdala and hippocampus.
J Pharmacol Sci. 2014; 125(3):329-32

Ohnishi N, Tahara Y, Kuriki D, Haraguchi A, Shibata S.
Warm water bath stimulates phase-shifts of the peripheral circadian clocks in PER2::LUCIFERASE mouse.
PLoS One. 2014 Jun 16;9(6):e100272

Nakamura Y, Ishimaru K, Tahara Y, Shibata S, Nakao A.
Disruption of the suprachiasmatic nucleus blunts a time of day-dependent variation in systemic anaphylactic reaction in mice.
J Immunol Res. 2014; 2014:474217

Kyoko OO, Kono H, Ishimaru K, Miyake K, Kubota T, Ogawa H, Okumura K, Shibata S, Nakao A.
Expressions of tight junction proteins Occludin and Claudin-1 are under the circadian control in the mouse large intestine: implications in intestinal permeability and susceptibility to colitis.
PLoS One. 2014 May 20;9(5):e98016

Aoki N, Watanabe H, Okada K, Aoki K, Imanishi T, Yoshida D, Ishikawa R, Shibata S.
Involvement of 5-HT₃ and 5-HT₄ receptors in the regulation of circadian clock gene expression in mouse small intestine.
J Pharmacol Sci. 2014; 124(2):262-75.

Tahara Y, Shibata S.
Chrono-biology, Chrono-pharmacology, and Chrono-nutrition.
J Pharmacol Sci. Review, 2014; 124(3):320-35



Nakamura Y, Nakano N, Ishimaru K, Hara M, Ikegami T, Tahara Y, Katoh R, Ogawa H, Okumura K, Shibata S, Nishiyama C, Nakao A.
Circadian Regulation of Allergic Reaction by the Mast Cell Clock in mice.
J Allergy Clin Immunol. 2014; 133(2):568-75

Horikawa K., Fuji K., Fukazawa Y., Shibata S.,
Two distinct serotonin receptors co-mediate non-photic signals to the circadian clock.
J Pharmacol Sci. 2013; 123(4):402-6

Tahara Y., Shibata S.
Chronobiology and nutrition.
Neuroscience. 2013; 253:78-88

Cermakian N, Lange T, Golombek D, Sarkar D, Nakao A, Shibata S, Mazzoccoli G.
Crosstalk between the circadian clock circuitry and the immune system.
Chronobiol Int. 2013; 30(7):870-88



Itokawa M, Hirao A, Nagahama H, Otsuka M, Ohtsu T, Furutani N, Hirao K, Hatta T, Shibata S.
Time-restricted feeding of rapidly digested starches causes stronger entrainment of the liver clock in PER2::LUCIFERASE knock-in mice.
Nutr Res. 2013 Feb;33(2):109-19

Kuroda H, Tahara Y, Saito K, Ohnishi N, Kubo Y, Seo Y, Otsuka M, Fuse Y, Ohura Y, Hirao A, Shibata S.
Meal frequency patterns determine the phase of mouse peripheral circadian clocks.
Scientific Reports. 2012;2:711

Takita E, Yokota S, Tahara Y, Hirao A, Aoki N, Nakamura Y, Nakao A, Shibata S.
Biological clock dysfunction exacerbates contact hypersensitivity in mice.
Br J Dermatol. 2013 Jan;168(1):39-46

Fuse Y, Hirao A, Kuroda H, Otsuka M, Tahara Y, Shibata S.
Differential roles of breakfast only (one meal per day) and a bigger breakfast with a small dinner (two meals per day) in mice fed a high-fat diet with regard to induced obesity and lipid metabolism.
J Circadian Rhythms. 2012 May 15;10(1):4

Tahara Y, Kuroda H, Saito K, Nakajima Y, Kubo Y, Ohnishi N, Seo Y, Otsuka M, Fuse Y, Ohura Y, Komatsu T, Moriya Y, Okada S, Furutani N, Hirao A, Horikawa K, Kudo T, Shibata S.
In vivo monitoring of peripheral circadian clocks in the mouse.
Current Biology. 2012 Jun 5;22(11):1029-34

Uchida Y, Osaki T, Yamasaki T, Shimomura T, Hata S, Horikawa K, Shibata S, Todo T, Hirayama J, Nishina H.
Involvement of the stress kinase mitogen-activated protein kinase kinase 7 in the regulation of the mammalian circadian clock.
J Biol Chem. 2012 Mar 9;287(11):8318-26

Hirao A, Furutani N, Nagahama H, Itokawa M, Shibata S.
The Protective and Recovery Effects of Fish Oil Supplementation on Cedar Pollen-Induced Allergic Reactions in Mice.
Food Nutrition and Sciences, 3(1):40-47, 2012. doi:10.4236/fns.2012.31008

Kubo Y, Tahara Y, Hirao A, Shibata S.
2,2,2-Tribromoethanol phase-shifts the circadian rhythm of the liver clock in Per2::Luciferase knockin mice: lack of dependence on anesthetic activity.
J Pharmacol Exp Ther. 2012 Mar;340(3):698-705


Okamoto M, Irii H, Tahara Y, Ishi H, Hirao A, Udagawa H, Hiramoto M, Yasuda K, Takanishi A, Shibata S, Shimizu I.
Synthesis of new [6]-gingerol analog and its protective effect on the development of metabolic syndrome in high-fat diet-fed mice.
J. Medicinal Chemistry. 2011 Sep 22;54(18):6295-304.

Sato-Mito N, Shibata S, Sasaki S, Sato K.
Dietary intake is associated with human chronotype as assessed by both morningness-eveningness score and preferred midpoint of sleep in young Japanese women.
Int J Food Sci Nutr. 2011 Aug;62(5):525-32

Sato-Mito N, Sasaki S, Murakami K, Okubo H, Takahashi Y, Shibata S, Yamada K, Sato K; the Freshmen in Dietetic Courses Study II group.
The midpoint of sleep is associated with dietary intake and dietary behavior among young Japanese women.
Sleep Med. 2011 Mar;12(3):289-94

Hayasaka N, Aoki K, Kinoshita S, Yamaguchi S, Wakefield JK, Tsuji-Kawahara S, Horikawa K, Ikegami H, Wakana S, Murakami T, Ramabhadran R, Miyazawa M, Shibata S.
Attenuated food anticipatory activity and abnormal circadian locomotor rhythms in Rgs16 knockdown mice.
PLoS One. 2011 Mar 9;6(3):e17655.

Nakamura Y, Harama D, Shimokawa N, Hara M, Suzuki R, Tahara Y, Ishimaru K, Katoh R, Okumura K, Ogawa H, Shibata S, Nakao A.
The circadian clock gene Period2 regulates a time of day-dependent variation in cutanenous anaphylactic reaction.
Journal of Allergy and Clinical Immunology. 2011 Apr;127(4):1038-45.

Yu Tahara, Makiko Otsuka, Yuta Fuse, Akiko Hirao, and Shigenobu Shibata
Refeeding after fasting elicits insulin-dependent regulation of Per2 and Rev-erba with shifts in the liver clock.
J Biological Rhythms. 2011 Jun;26(3):230-40

Naoto Hayasaka, Kazuyuki Aoki, Saori Kinoshita, Shoutaroh Yamaguchi, John K. Wakefield, Sachiyo Tsuji-Kawahara, Kazumasa Horikawa, Hiroshi Ikegami, Shigeharu Wakana, Takamichi Murakami, Ram Ramabhadran, Masaaki Miyazawa and Shigenobu Shibata.
Attenuated food anticipatory activity and abnormal circadian locomotor rhythms in Rgs16 knockdown mice.
PLoS One. 2011 Mar 9;6(3):e17655

Sato-Mito NSasaki SMurakami KOkubo HTakahashi YShibata SYamada KSato Kthe Freshmen in Dietetic Courses Study II group.  The midpoint of sleep is associated with dietary intake and dietary behavior among young Japanese women. Sleep Med. 12(3):289-294. 2011.




Sato-Mito N, Sasaki S, Murakami K, Okubo H, Takahashi Y, Shibata S, Yamada K, Sato K, and the Freshmen in Dietetic Courses Study-group.

The midpoint of sleep is associated with dietary intake and dietary behavior among young Japanese women. 
Sleep Medicine, 2010, in press

Hirao A, Nagahama H, Tsuboi T, Hirao M, Tahara Y, and Shibata S, 
Combination of starvation interval and food volume determines the phase of liver circadian rhythm in Per2::luc knock-in mice under two meals per day feeding.
Am J. Physiology,2010

 Matsumoto E, Ishihara A, Tamai S, Nemoto A, Iwase K, Hiwasa T, Shibata S, Takiguchi M.
Time-of-day and nutrients in feeding govern daily expre
ssion rhythms of the gene for sterol regulatory element-binding protein (SREBP)-1 in the mouse liver.
J Biol Chem. 2010 Aug 18.

Shibata S, Tahara Y, Hirao A. 
The adjustment and manipulation of biological rhythms by light, nutrition, and abused drugs.
Adv Drug Deliv Rev. Jun 23.,2010 review

Shibata S, Hirao A, Tahara Yu. 
Restricted feeding-induced entrainment of activity rhythm and peripheral clock rhythm .
Sleep and Biological Rhythms, 8, 18-27,2010 review

Ebisawa T, Numazawa K, Shimada H, Izutsu H, Sasaki T, Kato N, Tokunaga K, Mori A, Honma K, Honma S, Shibata S. 
Self-sustained circadian rhythm in cultured human mononuclear cells isolated from peripheral blood. 
Neurosci Res. 66:223-227.2010

 Ninomiya M, Numakawa T, Adachi N, Furuta M, Chiba S, Richards M, Shibata S, Kunugi H. 
Cortical neurons from intrauterine growth retardation rats exhibit lower response to neurotrophin BDNF.
Neurosci Lett. 476:104-109. 2010 .

Kajiyama Y, Iijima Y, Chiba S, Furuta M, Ninomiya M, Izumi A, Shibata S, Kunugi H. Prednisolone causes anxiety- and depression-like behaviors and altered expression of apoptotic genes in mice hippocampus.
Prog Neuropsychopharmacol Biol Psychiatry. 34:159-165.2010

Hamada T, Shibata S.
The role of GABAergic neuron on NMDA- and SP-induced phase delays in the suprachiasmatic nucleus neuronal activity rhythm in vitro. 
Neurosci Lett. 468:344-347. 2010

Tahara Y, Hirao A, Moriya T, Kudo T, Shibata S. 
Effects of medial hypothalamic lesions on feeding-induced entrainment of locomotor activity and liver Per2 expression in Per2::luc mice.
J Biol Rhythms. 25:9-18.2010

Yamamura Y, Yano I, Kudo T, Shibata S. 
Time-dependent inhibitory effect of lipopolysaccharide injection on Per1 and Per2 gene expression in the mouse heart and liver. 
Chronobiol Int. 27:213-232.2010


Hirao A, Tahara Y, Kimura I, Shibata S. 
A balanced diet is necessary for proper entrainment signals of the mouse liver clock.PLoS One. 4:e6909, 2009.

Mistlberger RE, Buijs RM, Challet E, Escobar C, Landry GJ, 

Kalsbeek A, Pevet P, Shibata S. 
Food anticipation in Bmal1-/- and AAV-Bmal1 rescued mice: a reply to Fuller et al. J Circadian Rhythms. 7:11, 2009.

Moriya T, Aida R, Kudo T, Akiyama M, Doi M, Hayasaka N, Nakahata N, Mistlberger R, Okamura H, Shibata S. 
The dorsomedial hypothalamic nucleus is not necessary for food-anticipatory circadian rhythms of behavior, temperature or clock gene expression in mice.
Eur J Neurosci. 29:1447-1460. 2009

Kudo T, Tamagawa T, Shibata S. 
Effect of chronic ethanol exposure on the liver of Clock-mutant mice.
J Circadian Rhythms. 7:4., 2009

Mistlberger RE, Buijs RM, Challet E, Escobar C, Landry GJ, Kalsbeek A, Pevet P, Shibata S. 
Standards of evidence in chronobiology: critical review of a report that restoration of Bmal1 expression in the dorsomedial hypothalamus is sufficient to restore circadian food anticipatory rhythms in Bmal1-/- mice. 
J Circadian Rhythms. 7, 3. ,2009, review




Kudo T, Kawashima M, Tamagawa T, Shibata S. 

“Clock mutation facilitates accumulation of cholesterol in the liver of mice fed a cholesterol and/or cholic acid diet.” 

Am J Physiol Endocrinol Metab. 2008 Jan

Iwahana E, Karatsoreos I, Shibata S, Silver R.
Gonadectomy reveals sex differences in circadian rhythms and suprachiasmatic nucleus androgen receptors in mice.
Horm. Behav.53,422-430.2008



Iwahana E , Hamada T, Uchida A, Shibata S

“Differential effect of lithium on the circadian oscillator in young and old hamsters.” 

Biochem Biophys Res Commun. 2007 Jan 18

Miyakawa K, Uchida A, Shiraki T, Teshima K, Takeshima H, Shibata S.

“ORL1 receptor-mediated down-regulation of mPER2 in the suprachiasmatic nucleus accelerates re-entrainment of the circadian clock following a shift in the environmental light/dark cycle. ”

 Biochem Biophys Res Commun. 2007 Jan 18

Hayasaka N , Yaita T, Kuwaki T, Honma S, Honma KI, Kudo T, Shibata S.

Optimization of Dosing Schedule of Daily Inhalant Dexamethasone to Minimize Phase-shifting of Clock Gene Expression Rhythm in the Lungs of the Asthma Mouse Model.” 

Endocrinology, Apr 5 2007

Wakatsuki YKudo TShibata S.

“Constant light housing during nursing causes human DSPS (delayed sleep phase syndrome) behaviour in Clock-mutant mice.” 

Eur J Neurosci. 2007 Apr

Shirai HOishi KKudo TShibata SIshida N.

“PPARalpha is a potential therapeutic target of drugs to treat circadian rhythm sleep disorders.” 

Biochem Biophys Res Commun. 2007 Apr 9

Kudo T, Tamagawa T, Kawashima M, Mito N, Shibata S. 

“Attenuating Effect of Clock Mutation on Triglyceride Contents in the ICR Mouse Liver under a High-Fat Diet.” 

J Biol Rhythms. 2007 Aug

Ishihara A, Matsumoto E, Horikawa K, Kudo T, Sakao E, Nemoto A, Iwase K, Sugiyama H, Tamura Y, Shibata S, Takiguchi M.

 “Multifactorial regulation of daily rhythms in expression of the metabolically responsive gene spot14 in the mouse liver.” 

J Biol Rhythms. 2007 Aug



Hoshino K, Wakatsuki Y, Iigo M, Shibata S . 
Circadian Clock mutation in dams disurupts nursing behavior and growth pups. Endocrinology. 147, 1916-1923.2006

Miyakawa KUchida AShiraki TTeshima KTakeshima HShibata S 

“ORL1 receptor-mediated down-regulation of mPER2 in the suprachiasmatic nucleus accelerates re-entrainment of the circadian clock following a shift in the environmental light/dark cycle.”

Neuropharmacology. 2006 Dec 27



Yokota S, Moriya T, Shibata S.

"Inhibitory Action of 5-HT(1A) Agonist MKC-242 on Triazolam-Induced Phase Advances in Hamster Circadian Activity Rhythms."

J Pharmacol Sci. 2005 May;98(1):103-6.

Iijima M, Yamaguchi S, van der Horst GT, Bonnefont X, Okamura H, Shibata S.

"Altered food-anticipatory activity rhythm in Cryptochrome- deficient mice."

Neurosci Res. 2005 Jun;52(2):166-73.

Horikawa K, Minami Y, Iijima M, Akiyama M and Shibata S.

“Rapid damping of food-entrained circadian rhythm of Clock gene expression in clock-defective peripheral tissues under fasting conditions”

Neuroscience. 2005 Jun 14

Teshima K, Minoguchi M, Tounai S, Ashimori A, Eguchi J, Charles N Allen and Shibata S.

“Nonphotic entrainment of the circadian body temperature rhythm by the selective ORL1 receptor agonist W-212393 in rats”

Br J Pharmacol. 2005 Jun 2



Iwahana E, Akiyama M, Miyakawa K, Uchida A, Kasahara J, Fukunaga K, Hamada T, Shibata S.

" Effect of lithium on the circadian rhythms of locomotor activity and glycogen synthase kinase-3 protein expression in the mouse suprachiasmatic nuclei."

Eur J Neurosci. 2004 Apr;19(8):2281-7.

Udo R, Hamada T, Horikawa K, Iwahana E, Miyakawa K, Otsuka K, Shibata S.

" The role of Clock in the plasticity of circadian entrainment."

BiochemBiophys Res Commun. 2004 Jun 11;318(4):893-8.

Kudo T, Akiyama M, Kuriyama K, Sudo M, Moriya T, Shibata S.

"Night-time restricted feeding normalises clock genes and Pai-1 gene expression in the db/db mouse liver. "

Diabetologia. 2004 Aug;47(8):1425-36.Epub 2004 Jul 29.

Kuriyama K, Sasahara K, Kudo T, Shibata S

" Daily injection of insulin attenuated impairment of liver circadian clock oscillation in the streptozotocin-treated diabetic mouse"

FEBS Lett. 2004 Jul:16 Volume 572, Issue 1-3, pp. 206-210

Kudo T, Nakayama E, Suzuki S, Akiyama M, Shibata S.

"Cholesterol Diet Enhances Daily Rhythm of Pai-1 mRNA in the Mouse Liver."

American Journal of Physiology Endocrinology and metabolism. 2004 Oct:287(4):E644-51

Horikawa K, Shibata S.

"Phase-resetting response to (+)8-OH-DPAT, a serotonin 1A/7 receptor agonist, in the mouse in vivo."

Neurosci Lett. 2004 Sep 23;368(2):130-4.

Shibata S. "Neural regulation of the hepatic Circadian rhythm."

Anat Rec. 2004 Sep 3;280A(1):901.

Akiyama M, Yuasa T, Hayasaka N, Horikawa K, Sakurai T, Shibata S.

“Reduced food anticipatory activity in genetically orexin (hypocretin) neuron-ablated mice.”

Eur J Neurosci. 2004 Dec;20(11):3054-62.



Mutoh T, Shibata S, Korf HW, Okamura H.

"Melatonin modulates the light-induced sympathoexcitation and vagal suppression with participation of the suprachiasmitic nucleus in mice."

J Physiol, 547.1,pp.317-332 2003

Moriya T, Ikeda M, Teshima K, Hara R, Kuriyama K, Yoshioka T, N Allen C, Shibata S.

"Facilitation of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor transmission in the suprachiasmatic nucleus by aniracetam enhances photic responses of the biological clock in rodents."

J. Neurochem 2003 May;85(4):978-987.

Akiyama M, Minami Y, Kuriyama K, Shibata S.

"MAP kinase-dependent induction of clock gene expression by alpha(1)-adrenergic receptor activation."

FEBS Lett. 2003 May 8;542(1-3):109-14

Terazono H, Mutoh T, Yamaguchi S, Kobayashi M, Akiyama M, Udo R, Ohdo S, Okamura H, Shibata S.

"Adregergic regulation of clock gene expression in the mouse liver."

Proc Natl Acad Sci USA 2003 May. vol.100 no.11 6795-6800

Sakao E, Ishihara A, Horikawa K, Akiyama M, Arai M, Kato M, Seki N, Fukunaga K, Shimizu-Yabe A, Iwase K, Ohtsuka S, Sato T, Kohno Y, Shibata S, Takiguchi M.

"Two-peaked synchronization in day/night expression rhythms of the fibrinogen gene cluster in the mouse liver."

J Biol Chem. 2003 Aug 15;278(33):30450-7.Epub 2003 May 14.

Sudo M, Sasahara K, Moriya T, Akiyama M, Hamada T, Shibata S.

"Constant Light Housing Attenuates Circadian Rhythms of mPer2 mRNA and mPER2 Protein Expression in the Suprachiasmatic Nucleus of Mice."




Aida R., Moriya T., Araki M., Akiyama M., Wada K., Wada E., Shibata S. 

Gastrin-releasing peptide mediates photicentrainable signals to the dorsal subsets of the suprachiasmatic nucleus via Induction of Period gene in mice. Mol.

Pharmacol. 2002 Jan;61(1):26-34.

Nishi M, Hashimoto K, Kuriyama K, Komazaki S, Kano M, Shibata S, Takeshima H.

Motor discoordination in mutant mice lacking junctophilin type 3.

BiochemBiophys Res Commun. 2002 Mar 29;292(2):318-24.

Takahashi S, Yoshinobu Y, Aida R, Shimomura H, Akiyama M, Moriya T, Shibata S.

Extended action of MKC-242, a selective 5-HT(1A) receptor agonist, on light-induced Per gene expression in the suprachiasmatic nucleus in mice.

J Neurosci Res. 2002 May 15;68(4):470-8.

Minami Y, Furuno K, Akiyama M, Moriya T, Shibata S.

Pituitary adenylate cyclase-activating polypeptide produces a phase shift associated with induction of mPer expression in the mouse suprachiasmatic nucleus.

Neuroscience. 2002;113(1):37-45.

Minami Y. Horikawa K, Akiyama M, Shibata S.

Restricted feeding induces daily expression of clock genes and Pai-1 mRNA in the heart of Clock mutant mice.

FEBS Lett. 2002 Aug 28;526(1-3):115-8.

Iijima M, Nikaido T, Akiyama M, Moriya T, Shibata S.

Methamphetamine-induced, suprachiasmatic nucleus-independent circadian rhythms of activity and mPer gene expression in the striatum of the mouse.

Eur J Neurosci. 2002 Sep;16(5):921-9

Nisikawa Y, Shimazoe T, Shibata S, Watanabe S.

Time-dependent effect of glutamate on long-term potentiation in the suprachiasmatic nucleus of rats.

J Pharmacol. 2002 Oct;90(2):201-4.

Fukunaga K, Horikawa K, Shibata S, Takeuchi Y, Miyamoto E.

Ca2+/calmodulin-dependent protein kinase II-dependent long-term potentiation in the rat suprachiasmatic nucleus and its inhibition by melatonin.

J Neurosci Res. 2002 Dec 15;70(6):799-807.



Wakamatsu, H., Takahashi, S., Moriya, T.,. Inouye, S-I., Okamura, H., Akiyama, M. and Shibata, S.

Additive effect of mPer1 and 2 antisense oligonucleotides on light-induced phase shift.

Neuroreport. 2001 Jan 22;12(1):127-31.

Yamaguchi,S., Kobayashi,M., Mitsui,S., Ishida,Y., van der Horst, G.T.J., Suzuki,M., Shibata,S., Okamura H.,

Real time monitoring of clock gene expression in the living mouse.

Nature. 2001 409,684.

Wakamatsu H., Yoshinobu Y., Aida R., Moriya T., Akiyama M. and Shibata S.,

Restricted feeding-induced activity rhythm is associated with expression rhythm of mPer1 and mPer2 mRNA in the cerebral cortex and hippocampus but not in the suprachiasmatic nucleus in mice.

Eur J Neurosci. 2001 Mar;13(6):1190-6.

Shimomura H., Moriya T., Sudo M., Wakamatsu H., Akiyama M., Shibata S.,

Differential Daily Expression of Per1 and Per2 mRNA in the Suprachiasmatic Nucleus of Fetal and Early Postnatal Mice.

Eur J Neurosci. 2001 Feb;13(4):687-93.

Nikaido T., Akiyama M., Moriya T., and Shibata S.,

Sensitized Increase of Period Gene Expression in the Mouse Caudate/Putamen Caused by Repeated Injection of Methamphetamine. Mol

Pharmacol. 2001 Apr;59(4):894-900.

Hara R., Wan K., Wakamatsu H., Aida R., Kuriyama K., Moriya T. , Akiyama M. and Shibata S.,

Restricted feeding entrains circadian clocks in the mouse liver without participation of suprachiasmatic nucleus.

Genes Cells. 2001 Mar;6(3):269-78.

Yokota, S-I., Yamamoto, M., Moriya, T., Akiyama, M., Fukunaga K., Miyamoto, E. and Shibata, S.

Involvement of Calcium-calmodulin Protein Kinase but not of Mitogen-activated Protein Kinase in Light-induced Phase Delay and Per Gene Expression in the Suprachiasmatic Nucleus of Hamster.

J Neurochem. 2001 Apr;77(2):618-27.

Yamamoto S, Shigeyoshi Y, Ishida Y, Fukuyama T, Yamaguchi S, Yagita K, Moriya T, Shibata S, Takashima N, Okamura H.

Expression of the Per1 gene in the hamster: Brain atlas and circadian characteristics in the suprachiasmatic nucleus.

J Comp Neurol. 2001 Feb 19;430(4):518-32.

Akiyama, M. Minami, Y., Nakajima, T., Moriya, T. and Shibata, S.

Calcium and pituitary adenylate cyclase-activating polypeptide induced expression of circadian clock gene mPer1 in the mouse cerebellar granule cell culture.

J Neurochem. 2001 Aug;78(3):499-508.

Takahashi S., Yokota S-I., Hara R., Kobayashi T., Akiyama M., Moriya T., Shibata S.

Physical and Inflammatory Stressors Elevate Circadian Clock Gene mPer1 mRNA Levels in the Paraventricular Nucleus of the Mouse.

Endocrinology. 2001 Nov;142(11):4910-7.

Asai M., Yoshinobu Y., Kaneko S., Mori A., Nikaido T., Moriya T., Akiyama M., Shibata S.,

Circadian profile of Per Gene mRNA expression in the suprachiasmatic nucleus, paraventricular nucleus, and pineal body of aged rats.

J Neurosci Res. 2001 Dec 15;66(6):1133-9.

1Asai M., Yamaguchi S., Isejima H., Jonouchi M., Moriya T., Shibata S., Kobayashi M., Okamura H.,

Visualization of mPer1 transcription in vitro: NMDA induces a rapid phase shift of mPer1 gene in cultured SCN.

Curr Biol. 2001 Oct 2;11(19):1524-7.



Stork O, Ji F, Kaneko K, Stork S, Yoshinobu Y, Moriya T, Shibata S, Obata K.

Postnatal development of a GABA deficit and disturbance of neural functions in mice lacking GAD65.

Brain Res. 2000 May 19;865(1):45-58.

Kouzu,Y., Moriya,T., Takeshima,H., Yoshioka,T., Shibata,S.,

Mutant mice lacking ryanodine receptor type 3 exhibit deficits of contextual fear conditioning and activation of calcium/calmodulin-dependent protein kinase II in the hippocampus.

Mol. Brain Res Mol Brain Res. 2000 Mar 10;76(1):142-50.

Takahiro Moriya, Yuko Yoshinobu, Yasuko Kouzu, Akira Katoh, Hiroshi Gomi, Masayuki Ikeda, Tohru Yoshioka, Shigeyoshi Itohara and Shigenobu Shibata ,

The essential role of GlialFibrillary Acidic Protein (GFAP)-expressing astrocytes in the mouse circadian oscillation under constant lighting condition,

J Neurosci Res. 2000 60, 212-218.

Kazumasa Horikawa, Shin-ichi Yokota, Kazuyuki Fuji, Masashi Akiyama, Takahiro Moriya,Hitoshi Okamura and Shigenobu Shibata.

Non-photic entrainment by 5-HT1A/7 receptor agonists accompanying with reduction of Per1 and Per2 expression.

J Neurosci. 2000 Aug 1;20(15):5867-73.

Yamaguchi S, Mitsui S, Miyake S, Yan L, Onishi H, Yagita K, Suzuki M, Shibata S, Kobayashi M, Okamura H.

The 5' upstream region of mPer1 gene contains two promoters and is responsible for circadian oscillation.

Curr Biol. 2000 Jul 13;10(14):873-6.

Ikeda M, Sugiyama T, Suzuki K, Moriya T, Shibata S, Katsuki M, Allen CN, Yoshioka T.

PLC beta 4-independent Ca2+ rise via muscarinic receptors in the mouse suprachiasmatic nucleus.

Neuroreport. 2000 Apr 7;11(5):907-12.

T. Moriya, S. Takahashi, M. Ikeda, K. Suzuki-Yamashita, M. Asai, H. Kadotani, H. Okamura, T. Yoshioka and S. Shibata,

N-metyl-D-aspartate receptor subtype 2C is not involved in the circadian oscillation or photic entrainment of the biological clock in mice.

J Neurosci Res. 2000 Sep 15;61(6):663-73.

Takahiro Moriya, Yasuko Kouzu, Shigenobu Shibata, Hiroshi Kadotani, , Kohji Fukunaga, Eishichi Miyamoto and TohruYoshioka.,

Close linkage between Calcium/ CalmodulinKinase II a/β and NMDA-2A receptors in the lateral amygdala and significance for retrieval of auditory fear conditioning.

Eur J Neurosci. 2000 Sep;12(9):3307-14.

Asai M, Ikeda M, Akiyama M, Oshima I, Shibata S,

Administration of melatonin in drinking water promotes the phase advance of light-dark cycle in senescence-accelerated mice, SAMR1 but not SAMP8.

Brain Res. 2000 Sep 8;876(1-2):220-4.

Moriya T., Horikawa K, Akiyama M, Shibata S,.

Correlative association between N-Methyl-D-Aspartate (NMDA) Receptor-Mediated Expression of Period Genes in the Suprachiasmatic Nucleus and Phase Shifts in Behavior with Photic Entrainment of Clock in Hamsters.

Mol Pharmacol. 2000 Dec;58(6):1554-62.

Shin-ichi Yokota, Kazumasa Horikawa, Masashi Akiyama, Takahiro Moriya, ShizufumiEbihara, TakuroOhta, and Shigenobu Shibata.

Inhibitory Action of Brotizolam on Circadian and Light-induced Per1 and Per2 Expression in the Hamster Suprachiasmatic Nucleus.

Br J Pharmacol. 2000 Dec;131(8):1739-47.

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